Sarah Neumeyer and Takanobu Tagawa

• PMID: 39541833

• DOI: 10.1016/j.virol.2024.110286

Kaposi sarcoma herpesvirus (KSHV) is an oncogenic DNA virus associated with various malignancies, including tumours like Kaposi sarcoma and Primary effusion lymphoma. Recently, the importance of the tumour microenvironment in KSHV-associated tumours is being studied. New studies utilizing human primary cells, co-culture experiments with KSHV-infected cells, and modern techniques like time-resolved single cell analysis, have significantly advanced the understanding of KSHV interactions with monocytes and macrophages. These cells play key roles in shaping the tumour microenvironment. It has become clear that KSHV-infected endothelial cells regulate the growth and the differentiation of monocytes and macrophages. Monocytes and macrophages, in turn, can regulate KSHV-infected cells in tumorigenesis and cytokine secretion, leading to the pro-tumour microenvironment. Further investigations into the viral regulation of monocytes and macrophages thus have potential to lead to the discovery of novel antitumour therapeutics.

https://www.embopress.org/doi/full/10.1038/s44319-023-00051-z

More detail

Ramaswami, R., T. Tagawa, G. Mahesh, A. Serquina, V. Koparde, K. Lurain, S. Dremel, X. Li, A. Mungale, A. Beran, Z.W. Ohler, L. Bassel, A. Warner, R. Mangusan, A. Widell, I. Ekwede, L.T. Krug, T.S. Uldrick, R. Yarchoan, and J.M. Ziegelbauer. In press. Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis. J. Transl. Med. doi: 10.1101/2022.03.18.484923.

Tagawa, T., D. Oh, S. Dremel, G. Mahesh, V.N. Koparde, G. Duncan, T. Andresson, and J.M. Ziegelbauer. 2023. A virus-induced circular RNA maintains latent infection of Kaposi’s sarcoma herpesvirus. Proc National Acad Sci. 120:e2212864120. doi:10.1073/pnas.2212864120.

Click here for more detail.

Albanese, M., T. Tagawa, and W. Hammerschmidt. 2022. Strategies of Epstein-Barr virus to evade innate antiviral immunity of its human host. Front Microbiol. 13:955603. doi:10.3389/fmicb.2022.955603.

IDETA, Y., T. TAGAWA, Y. HAYASHI, J. BABA, K. TAKAHASHI, K. MITSUDO, and K. SAKURAI. 2021. Transcriptomic Profiling Predicts Multiple Pathways and Molecules Associated With the Metastatic Phenotype of Oral Cancer Cells. Cancer Genom - Proteom. 18:17–27. doi:10.21873/cgp.20238.

Bouvet, M., S. Voigt, T. Tagawa, M. Albanese, Y.-F.A. Chen, Y. Chen, D.N. Fachko, D. Pich, C. Göbel, R.L. Skalsky, and W. Hammerschmidt. 2021. Multiple Viral microRNAs Regulate Interferon Release and Signaling Early during Infection with Epstein-Barr Virus. Mbio. 12:e03440-20. doi:10.1128/mbio.03440-20.

Serquiña, A.K.P., T. Tagawa, D. Oh, G. Mahesh, and J.M. Ziegelbauer. 2021. 25-Hydroxycholesterol Inhibits Kaposi’s Sarcoma Herpesvirus and Epstein-Barr Virus Infections and Activates Inflammatory Cytokine Responses. Mbio. 12:e02907-21. doi:10.1128/mbio.02907-21.

Albanese, M., Y.-F.A. Chen, C. Hüls, K. Gärtner, T. Tagawa, E. Mejias-Perez, O.T. Keppler, C. Göbel, R. Zeidler, M. Shein, A.K. Schütz, and W. Hammerschmidt. 2021. MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells. Plos Genet. 17:e1009951. doi:10.1371/journal.10.1371/journal.pgen.1009951.

Tagawa, T., V.N. Kopardé, and J.M. Ziegelbauer. 2021. Identifying and characterizing virus-encoded circular RNAs. Methods. 196:129–137. doi:10.1016/j.ymeth.2021.03.004.

Click here for more detail

Tagawa, T., D. Oh, J. Santos, S. Dremel, G. Mahesh, T.S. Uldrick, R. Yarchoan, V.N. Kopardé, and J.M. Ziegelbauer. 2021. Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs. Front Microbiol. 12:670542. doi:10.3389/fmicb.2021.670542.

Click here for more detail

Tagawa, T., A. Serquiña, I. Kook, and J. Ziegelbauer. 2020. Viral non-coding RNAs: Stealth strategies in the tug-of-war between humans and herpesviruses. Semin Cell Dev Biol. 111:135–147. doi:10.1016/j.semcdb.2020.06.015.

Schaeffner, M., P. Mrozek-Gorska, A. Buschle, A. Woellmer, T. Tagawa, F.M. Cernilogar, G. Schotta, N. Krietenstein, C. Lieleg, P. Korber, and W. Hammerschmidt. 2019. BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV. Life Sci Alliance. 2:e201800108. doi:10.26508/lsa.201800108.

Danisch, S., C. Slabik, A. Cornelius, M. Albanese, T. Tagawa, Y.-F.A. Chen, N. Krönke, B. Eiz-Vesper, S. Lienenklaus, A. Bleich, S.J. Theobald, A. Schneider, A. Ganser, C. von Kaisenberg, R. Zeidler, W. Hammerschmidt, F. Feuerhake, and R. Stripecke. 2018. Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1–Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice. Am J Pathology. 189:521–539. doi:10.1016/j.ajpath.2018.11.014.

Davis, D.A., P. Shrestha, A.I. Aisabor, A. Stream, V. Galli, C.A. Pise-Masison, T. Tagawa, J.M. Ziegelbauer, G. Franchini, and R. Yarchoan. 2018. Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells. Oncoimmunology. 8:1–16. doi:10.1080/2162402x.2018.1546544.

Tagawa, T., S. Gao, V.N. Koparde, M. Gonzalez, J.L. Spouge, A.P. Serquiña, K. Lurain, R. Ramaswami, T.S. Uldrick, R. Yarchoan, and J.M. Ziegelbauer. 2018. Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA. Proc National Acad Sci. 115:201816183. doi:10.1073/pnas.1816183115.

Click here for more detail

Albanese, M., T. Tagawa, A. Buschle, and W. Hammerschmidt. 2017. MicroRNAs of Epstein-Barr Virus Control Innate and Adaptive Antiviral Immunity. J Virol. 91:e01667-16. doi:10.1128/jvi.01667-16.

Albanese, M., T. Tagawa, M. Bouvet, L. Maliqi, D. Lutter, J. Hoser, M. Hastreiter, M. Hayes, B. Sugden, L. Martin, A. Moosmann, and W. Hammerschmidt. 2016. Epstein–Barr virus microRNAs reduce immune surveillance by virus-specific CD8+ T cells. Proc National Acad Sci. 113:E6467–E6475. doi:10.1073/pnas.1605884113.

Tagawa, T., M. Albanese, M. Bouvet, A. Moosmann, J. Mautner, V. Heissmeyer, C. Zielinski, D. Lutter, J. Hoser, M. Hastreiter, M. Hayes, B. Sugden, and W. Hammerschmidt. 2016. Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing. J Exp Med. 213:2065–2080. doi:10.1084/jem.20160248.